Adoptive Immunotherapy for Epstein-Barr Virus-Related Lymphoma
- 1 January 1996
- journal article
- research article
- Published by Taylor & Francis in Leukemia & Lymphoma
- Vol. 23 (3-4) , 213-220
- https://doi.org/10.3109/10428199609054823
Abstract
Epstein-Barr virus (EBV) causes opportunistic B cell lymphomas in patients whose cellular immunity is compromised. We have been investigating whether infusions of donor-derived, EBV-specific cytotoxic T cells can prevent and/or treat EBV-related lymphoproliferative disease in children receiving T cell-depleted bone marrow from HLA-matched, unrelated or HLA-mismatched, related donors. In this review, we discuss the rationale for this therapeutic approach, describe our experiences with the regimen thus far, and consider some future directions in immunotherapy.Keywords
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