Human neuroblastoma serially transplanted in nude mice and metastases
- 1 August 1978
- Vol. 42 (2) , 468-473
- https://doi.org/10.1002/1097-0142(197808)42:2<468::aid-cncr2820420214>3.0.co;2-7
Abstract
A human neuroblastoma from a female patient was directly transplanted into nude mice and serial transplantation was established. Histology of the transplanted tumor was almost the same as that of the patient. During serial transplantation, a high frequency of metastasis to distant organs such as ovaries, lymph node and cerebrum was observed, especially in the ovaries where the metastatic rate reached to 66%. Regarding the distribution of organs involved, there is close similarity between that in the patient with neuroblastoma and tumor-bearing mice. This transplantable human neuroblastoma provides a unique research tool for studies on its morphological and biological nature, including metastasis.This publication has 5 references indexed in Scilit:
- Transplantation of Human Tumors in Nude Mice23JNCI Journal of the National Cancer Institute, 1976
- Human Gastric Choriocarcinoma Serially Transplanted in Nude Mice2JNCI Journal of the National Cancer Institute, 1976
- Heterotransplantation of Human Malignant Tumors in “Nude” Thymusless Mice. II. Malignant Tumors Induced by Injection of Cell Cultures Derived From Human Solid Tumors 2JNCI Journal of the National Cancer Institute, 1974
- Metastases of Human Melanomas Transplanted in “Nude” Mice2JNCI Journal of the National Cancer Institute, 1973
- HETEROTRANSPLANTATION OF A HUMAN MALIGNANT TUMOUR TO “NUDE” MICEActa Pathologica Microbiologica Scandinavica, 1969