GLUCOSE UTILIZATION IN PREGNANT SHEEP

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Abstract
By using the constant-infusion isotope-dilution method, pregnant sheep have been shown to utilize glucose at the rate of l.29[plus or minus]0.11 mg./min./kg. There was no significant difference between normal and ketotic sheep. Under steady-state conditions the CO2 ratio, i.e. the specific radioactivity of expired CO2 during the infusion of [1-14C] glucose divided by the specific radioactivity of expired CO2 during the infusion of [6-14C] glucose, was 1.60[plus or minus]0.18. Under steady-state conditions the mean CO2 production was 10.2[plus or minus]0.35 m-moles/min. The percentage of CO2 derived from glucose ranged from 1.7 to 2.4 and the percentage of glucose utilized that was oxidized to CO2 ranged from 5.5 to 9.5. These results have been contrasted with those obtained from 2 non-pregnant sheep on a similar diet. The latter utilized glucose at the rate of 1.84[plus or minus]0.1 (2) mg./min./kg. and produced CO2 at the rate of 6.8 and 4.8 m-moles/min. The percentage of CO2 derived from glucose was 2.1 and 3.7 and the percentage of glucose utilized that was oxidized to CO2 was 3.5 and 4.7.