Increased Sister-Chromatid Exchange in Multiple Sclerosis
- 6 November 1980
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 303 (19) , 1126
- https://doi.org/10.1056/nejm198011063031921
Abstract
To the Editor: The analysis of rates of sister-chromatid exchange (SCE) has been shown to be a sensitive method of measuring DNA damage.1 SCE is increased after exposure to many mutagens and carcinogens2 and in some viral illnesses.3 During a study of persons exposed to a variety of environmental agents during pregnancy, we encountered a woman with multiple sclerosis (MS) who had an unexplained elevation of SCE. This incidental finding was followed up, and it was found that SCE is increased in MS.Volunteers were sought from the South Australian MS-rehabilitation unit, and blood samples were collected from inpatients with . . .Keywords
This publication has 5 references indexed in Scilit:
- In vivo sister-chromatid exchange: A sensitive measure of DNA damageMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1979
- Sister chromatid exchange in patients with viral diseaseExperimental Cell Research, 1978
- MULTIPLE SCLEROSIS: A VIRUS DISEASE?British Medical Bulletin, 1977
- Anomalous lymphocyte-antigen reaction in relatives of multiple sclerosis patientsZeitschrift für Neurologie, 1977
- Cytological detection of mutagen–carcinogen exposure by sister chromatid exchangeNature, 1975