THE CHOICE OF OVARIAN OR PITUITARY THERAPY FOR MENSTRUAL DISTURBANCES

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Abstract
Ovarian dysfunction includes a variety of decreased activities of hormone production, either primary or secondary to ant. pituitary hypofunction. Since ovarian hormones do not stimulate the ovaries, these preps. should be reserved for replacement therapy, as in the climacteric. Stimulation of human ovaries may be accomplished by hypodermic use of gonadotropic extracts from the ant. pituitary or from pregnant mare''s serum. Superior results are to be expected from the repeated use of small doses, limited usually to the first 2 wks. of each menstrual cycle. Intraven. inj. of larger doses may be of service in initiating ovulation. For both diagnostic criteria and estimation of progress under therapy one may use not only improved menstrual rhythm, but vaginal epithelial smears, endometrial biopsies, and estimations of pregnandiol excretion.

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