Treatment of Acute SIV infection in cynomolgus Monkeys with 2′,3′-dideoxyinosine (ddl) and 2′,3′-dideoxythymidiene (d4T)

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Abstract
2′,3′-dideoxyinosine (ddl) and 2′,3′-dideoxythymidiene (d4T) have been reported to inhibit the multiplication of human immunodeficiency virus (HIV) in patients, ddl and d4T were administered subcutaneously to cynomolgus monkeys starting 8 h prior to inoculation with 10–50 infectious doses of simian immunodeficiency virus (SIVSM). ddl, at a daily dose of 3 × 3.6 mg kg−1 for 10 days significantly delayed the appearance of SIVSM p24/26 antigen. A significant delay in the appearance of SIVSM p24/26 antigen was also seen when using a daily dose of 3 × 1 mg kg −1 of d4T for 10 days. Neither ddl nor d4T prevented SIVSM infection despite administration prior to virus inoculation.