Functional Studies of the Extrahepatic Biliary System in the Dog by Use of a Controlled Biliary Fistula

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Abstract
A semipermanent biliary fistula was developed to facilitate perfusion of the biliary tree at a controlled rate and to allow for simultaneous pressure measurements. Studies were made on 218 occasions in the conscious and unconscious animal. A method was contrived of relating pressure measurements to sphincter function as studied with the aid of a telecine (kine-record) cholangiogram. Results of these studies suggest that the interpretation of pressure changes in the extrahepatic biliary system are vulnerable to criticism. The method of investigation was found to be useful in facilitating studies in the experimental animal over a long period.