THE EFFECT OF CORTISONE AND THYROTROPHIN ON THYROID TRANSPLANTS IN THE GUINEA-PIG
- 1 July 1954
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 11 (1) , 1-+
- https://doi.org/10.1677/joe.0.0110001
Abstract
SUMMARY: Administration of cortisone in large dosage (20 mg daily) decreases the chances of survival of thyroid autotransplants in guinea-pigs. Despite this, cortisone may facilitate the survival of thyroid homotransplants, apparently by inhibiting the development of resistance in the host. The effect is a slight one, however, and is not apparent when transplants are made from stock donors to members of a highly inbred strain. Administration of thyrotrophin does not abolish the deleterious effect of cortisone on autotransplants, nor does it appear to facilitate the survival of homotransplants.Keywords
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