THE BASIS OF DDT TOLERANCE IN THE LABORATORY MOUSE

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Abstract
DDT tolerance in the Macdonald strain of the laboratory mouse is shown to be related to lipid content. Relatively large amounts of sesame oil injected into DDT-treated mice, either with the DDT or up until the symptoms of poisoning appeared, protected the recipients from severe symptoms and death. DDT-tolerant mice excreted14C-labelled DDT or its metabolites in the urine, at a significantly lower rate than the normal mice. DDT-susceptible mice excreted 8 to 10% of the injected dose of DDT within 12 days. DDT tolerance could not be related to the production of DDE or TDE.