Selective inhibitors of cyclooxygenase-2
- 1 January 1997
- journal article
- Published by Informa Healthcare in Expert Opinion on Therapeutic Patents
- Vol. 7 (1) , 55-62
- https://doi.org/10.1517/13543776.7.1.55
Abstract
Prostaglandins (PGs) produced by the inducible enzyme cyclooxygenase-2 (COX-2) are important mediators of pain and inflammation. In animals, selective inhibitors of COX-2 have been shown to be anti-inflammatory without typical non-steroidal anti-inflammatory drug (NSAID) side-effects. Research directed towards the identification of potent and selective inhibitors of COX-2 has made significant advances in recent years. The current different structural classes of COX-2 inhibitors are discussed, with an emphasis on the most recent primary and patent literature. Early human clinical results indicate that COX-2 inhibitors offer a significant advancement for the treatment of inflammatory disease states.Keywords
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