COMPARISON OF CUMULATIVE AND SINGLE BOLUS DOSE TECHNIQUES FOR DETERMINING THE POTENCY OF VECURONIUM
Open Access
- 1 November 1985
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 57 (11) , 1060-1062
- https://doi.org/10.1093/bja/57.11.1060
Abstract
The potency of vecuronium was determined using single bolus dose administrations of 10–50 μg kg−1in 28 patients anaesthetized with thiopentone, nitrous oxide, oxygen and fentanyl. The results were compared with those previously obtained using a cumulative dose technique in a comparable group of 10 patients. The 50% and 95% blocking doses (ED50and ED95) of vecuronium were found to be 23.1 and 39.6 μg kg−1, respectively. These were significantly lower than the 30.5 and 56.7μg kg−1 obtained previously using the cumulative dose technique. We recommend the use of single bolus dose method of determining potency for relatively shorter-acting drugs like vecuronium.Keywords
This publication has 1 reference indexed in Scilit:
- Dose‐response studies with pancuronium, vecuronium and their combination.British Journal of Clinical Pharmacology, 1984