A secondary progressive clinical course is uncommon in neuromyelitis optica
Top Cited Papers
- 20 February 2007
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 68 (8) , 603-605
- https://doi.org/10.1212/01.wnl.0000254502.87233.9a
Abstract
We compared the clinical course of 96 patients with neuromyelitis optica (NMO) to multiple sclerosis (MS) natural history data. Based on the distribution of follow-up data (median 6.1 year), we estimated that 21 NMO patients would convert to a secondary progressive course, but we observed only two conversions (p = 0.00002; relative risk = 0.08). The disparate natural histories of MS and NMO suggest dissociation between relapses and clinical progression in CNS demyelinating diseases.Keywords
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