I-region linked complementing loci in resistance to viral leukemogenesis in the mouse

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Abstract
A-RadLV, a variant of the radiation leukemia virus, inoculated intrathymically into adult mice, causes a high frequency of leukemia in haplotypesb, f, k, d, p andj on the B10 background, whereas H-2S mice are resistant. Resistance is dominant and segregates withH-2 S in the offspring of (b×s)b and (b×t 2)b backcrosses. Analysis of recombinant strains revealed that resistance is associated withI-A andI-B. B10.A(5R), a recombinant of two sensitive haplotypes, was found to be resistant, suggesting intra-H-2-gene complementation. The resistance of such complementing loci was demonstrated also in thetrans position by testing F1 mice bred from sensitive parents. These data are taken to suggest thatI-region linked complementing loci, similar to classicalIr genes, may be involved in resistance to murine leukemia.