Synthesis of C2-symmetric inhibitors of the HIV-1 protease, with N,N′-substituted ethylenediamide and ethylenediamine linkers.
- 1 March 1994
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 4 (5) , 653-656
- https://doi.org/10.1016/s0960-894x(01)80173-6
Abstract
No abstract availableKeywords
This publication has 19 references indexed in Scilit:
- Inhibition of human immunodeficiency virus-1 protease by a C2-symmetric phosphinate. Synthesis and crystallographic analysisBiochemistry, 1993
- Synthesis of 1,3-diamino-2-hydroxypropane derivatives as pseudosymmetric HIV protease inhibitorsBioorganic & Medicinal Chemistry Letters, 1993
- Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diolJournal of Medicinal Chemistry, 1993
- A symmetric inhibitor binds HIV-1 protease asymmetricallyBiochemistry, 1993
- Preclinical evaluation of antiviral activity and toxicity of Abbott A77003, an inhibitor of the human immunodeficiency virus type 1 proteaseAntimicrobial Agents and Chemotherapy, 1993
- Synthesis of C2-symmetric HIV-1 protease inhibitors from D-mannitolBioorganic & Medicinal Chemistry Letters, 1992
- Inhibitors of HIV-1 ProteaseJournal of Enzyme Inhibition, 1992
- X-ray crystal structure of the HIV protease complex with L-700,417, an inhibitor with pseudo C2 symmetryJournal of the American Chemical Society, 1991
- Structure-based, C2 symmetric inhibitors of HIV proteaseJournal of Medicinal Chemistry, 1990
- Design, Activity, and 2.8 Å Crystal Structure of a C 2 Symmetric Inhibitor Complexed to HIV-1 ProteaseScience, 1990