Technic of Controlled Drug Assay

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Abstract
THE results of evaluation of hypotensive drugs by methods that involve consideration of certain nonpharmacologic variables were described in previous reports.1 2 3 These variables, which include the effect of the doctor–patient relation and the impact of psychologic changes in the patient, may mimic and occasionally mask pharmacologic effects and must be evaluated to define precisely the clinical uses and limitations of the hypotensive agents. The design of previous studies included the use of a double-blind placebo alternation, in which each patient served as his own control. All patients in a group were seen by one investigator, which allowed for a relative . . .