6-Aminopenicillanic acid II. Formation of 6-aminopenicillanic acid by Emericellopsis minima (Stolk) and related fungi

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Abstract
In submerged culture, Emericellopsis minima (Stolk) I. M. I. 69015 produced a substance resembling 6-aminopenicillanic acid in its behaviour on paper chromatograms and in its properties after reaction with phenylacetyl chloride. The substance was destroyed by peni­cillinase but was acid-stable. The culture also produced cephalosporin N and two unidentified antibiotics which have been named emericellopsin A and B . When other fungi of the genera Emericellopsis and Gephalosporium were examined in a similar manner, C , salmosynnematum and Cephalosporium I. M. I. 49137 were also found to produce small amounts of a substance resembling 6-aminopenicillanic acid. Examination of Emericellopsis minima (Stolk) also showed the presence of penicillin amidase activity in this culture.