Multiple Myeloma and the Nephrotic Syndrome. A Biochemical and Morphologic Study

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Abstract
A renal biopsy was obtained from a patient with the rare association of multiple myeloma and nephrotic syndrome. Light and electron microscopic investigation of this tissue disclosed extensive glomerular mesangial foam cell change and unusual basement membrane alterations. Analysis of serum revealed a marked increase of IgA [immunoglobulin A] protein and provided to suggest that this myeloma protein complexed with low density lipoproteins. Such a protein-lipid interaction may have provided the stimulus for some of the glomerular abnormalities.

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