A study of the regioselectivity of oxygen insertion in the Baeyer–Villiger oxidation of bicyclo[2.2.1]heptan-2-ones
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 8,p. 1793-1802
- https://doi.org/10.1039/p19910001793
Abstract
Synthesis and Baeyer–Villiger oxidation of the series of bicyclic ketones 3 and 6 is described. The ratio of methine to methylene carbon migration in the oxidation was found to vary depending on the 5-endo and 7-anti substituents of the ketones. Possible reasons for the observed regioselectivity are discussed.Keywords
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