Effect of Cortisone Acetate upon Plasma Amino Acids in the Eviscerate Rat

Abstract
Male rats were eviscerated and eviscerated-adrenalecto-mized. All received continuous intraven. infusions of saline with glucose and insulin for 24 and 48 hrs. The admn. of cortisone acetate in doses of 5 and 10 mg./24 hrs. to one rat of each pair caused significant increases in the plasma amino acids above the values for untreated animals. The observed change apparently represents an extra-hepatic effect of cortisone upon protein metabolism.