Ocular Anti-inflammatory Effects of Fenoprofen
- 1 December 1974
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 92 (6) , 506-508
- https://doi.org/10.1001/archopht.1974.01010010520012
Abstract
Fenoprofen sodium 1% at a pH of 6.4 was found to have comparable efficacy with 0.1% dexamethasone in the topical therapy of an experimental rabbit uveitis model. Increase in pH of fenoprofen to 7.4 resulted in efficacy indistinguishable from the vehicle alone. Since the drug is more ionized at alkaline pH, this decrease in efficacy may have resulted from decreased corneal penetration of a more polarized molecule.Keywords
This publication has 5 references indexed in Scilit:
- Indomethacin in Ocular Inflammation in RabbitsArchives of Ophthalmology (1950), 1967
- The Heritable Nature of Dexamethasone-Induced Ocular HypertensionArchives of Ophthalmology (1950), 1966
- Effect of Corticosteroids on Intraocular Pressure and Fluid Dynamics I. Effect of Dexamethasone in the Normal EyesJAMA, 1963
- TREATMENT OF HERPES ZOSTER OPHTHALMICUS WITH CORTISONE OR CORTICOTROPINArchives of Ophthalmology (1950), 1955
- Effect of Cortisone on Healing of Corneal WoundsBritish Journal of Ophthalmology, 1951