Austritt aus dem Endothelium und Freisetzung von Histamin bei intravaskulärem Kontrastmittel

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Abstract
The endothelial injury produced by meglumine iodamide was studied in the rat aorta. A mixture of blood and contrast medium was more toxic to the endothelium than the pure contrast agent. This difference disappeared after premedication with antihistamine, which did not affect the injury produced by the pure contrast agent. Meglumine iodamide appears to cause a release of histamine from blood but not from the aortic endothelium nor from surrounding tissues in amounts demonstrable by this method. Leukocytes are a source of histamine after intravascular contrast medium administration.