A DIRECT MEASUREMENT OF HEPATIC GLUCOSE PRODUCTION IN EXPERIMENTAL DIABETES MELLITUS

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Abstract
Hepatic blood flow and glucose output were detd. at intervals after withdrawal of food and insulin from depancreatized dogs and the data compared with previous observations on normal animals. There is no significant difference between glucose output by the liver in depancreatized dogs and in normal dogs. In the diabetic dog, 68% of the hepatic glucose output appears in the urine. The 32% of the hepatic glucose output which is retained does not appear adequate to supply the glucose utilized by central nervous system and gastrointestinal tract. The possibility of extrahepatic glucose production is considered. The data are believed to present further evidence that the G: N ratio is invalid.

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