Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus
Top Cited Papers
- 15 March 2016
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 90 (6) , 3253-3256
- https://doi.org/10.1128/jvi.02582-15
Abstract
We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.Keywords
Funding Information
- National Natural Science Foundation of China (81290341, 31321001)
- Minister of Science and Technology of the People's Republic of China (2014ZX10004001-003, 2013FY113500)
- HHS | National Institutes of Health (NIAID R01AI110964)
- National Research Foundation Singapore (NRF2012NRF-CRP001-056)
This publication has 14 references indexed in Scilit:
- ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome CoronavirusThe Journal of Infectious Diseases, 2015
- Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptorNature, 2013
- Evidence for a Common Evolutionary Origin of Coronavirus Spike Protein Receptor-Binding SubunitsJournal of Virology, 2012
- Genomic Characterization of Severe Acute Respiratory Syndrome-Related Coronavirus in European Bats and Classification of Coronaviruses Based on Partial RNA-Dependent RNA Polymerase Gene SequencesJournal of Virology, 2010
- Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysisJournal of General Virology, 2006
- Bats Are Natural Reservoirs of SARS-Like CoronavirusesScience, 2005
- Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe batsProceedings of the National Academy of Sciences, 2005
- Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and humanProceedings of the National Academy of Sciences, 2005
- Severe acute respiratory syndromeNature Medicine, 2004
- Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern ChinaScience, 2003