Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China
Top Cited Papers
- 10 October 2003
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 302 (5643) , 276-278
- https://doi.org/10.1126/science.1087139
Abstract
A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides ) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.Keywords
This publication has 6 references indexed in Scilit:
- The Genome Sequence of the SARS-Associated CoronavirusScience, 2003
- A Novel Coronavirus Associated with Severe Acute Respiratory SyndromeNew England Journal of Medicine, 2003
- Koch's postulates fulfilled for SARS virusNature, 2003
- Coronavirus as a possible cause of severe acute respiratory syndromeThe Lancet, 2003
- MEGA2: molecular evolutionary genetics analysis softwareBioinformatics, 2001
- A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequencesJournal of Molecular Evolution, 1980