LUNG SURFACTANT: A Personal Perspective
- 1 October 1997
- journal article
- autobiography
- Published by Annual Reviews in Annual Review of Physiology
- Vol. 59 (1) , 1-21
- https://doi.org/10.1146/annurev.physiol.59.1.1
Abstract
▪ Abstract This perspective tells the story of the discovery, characterization, and understanding of the surfactant system of the lung; of how investigators from many disciplines studied the system, stimulated by the demonstration of surfactant deficiency in respiratory distress syndrome of the newborn; and of how the resulting knowledge formed a basis for highly successful surfactant substitution treatment for this syndrome. The chapter includes personal reminiscences and reflections of the author and ends with a few thoughts about the present status and future prospects of this field of research.Keywords
This publication has 59 references indexed in Scilit:
- Pulmonary surfactant‐associated polypeptide SP‐C in lipid micelles: CD studies of intact SP‐C and NMR secondary structure determination of depalmitoyl‐SP‐C(1–17)FEBS Letters, 1995
- Deficiency of Pulmonary Surfactant Protein B in Congenital Alveolar ProteinosisNew England Journal of Medicine, 1993
- Effects of two rescue doses of a synthetic surfactant on mortality rate and survival without bronchopulmonary dysplasia in 700- to 1350-gram infants with respiratory distress syndromeThe Journal of Pediatrics, 1991
- Effects of a protein-free, synthetic surfactant on survival and pulmonary function in preterm lambsThe Journal of Pediatrics, 1985
- Subfractionation of lung surfactant implications for metabolism and surface activityBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1983
- Precursor-product relationship between rabbit type II cell lamellar bodies and alveolar surface-active materialBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1981
- Analysis of Labeling and Clearance of Lung Surfactant Phospholipids in RabbitJournal of Clinical Investigation, 1981
- Freeze-fracture study of alveolar lining layer in adult rat lungsJournal of Ultrastructure Research, 1979
- Improvements in demonstration of lining layer of lung alveoli by electron microscopyRespiration Physiology, 1969
- Correlations of Mechanical Stability, Morphology, Pulmonary Surfactant, and Phospholipid Content in the Developing Lamb Lung*Journal of Clinical Investigation, 1967