Inhibitory Effects of Hydrochloric Acid in Antrum and Duodenum on Gastric Secretory Responses to Test Meal in Pavlov and Heidenhain Pouch Dogs

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Abstract
Instillation of hydrochloric acid into the excluded duodenum inhibits the gastric secretion stimulated by test meal in both Pavlov and Heidenhain pouch dogs. This is in accordance with the assumption by several authors that a secretion‐inhibiting mechanism is activated by an acid milieu in the duodenum. The results also show that this mechanism operates independent of the vagal nerve supply to the gastric mucosa. Perfusion of an isolated antral pouch with hydrochloric acid had lesser and irregularly occurring inhibitory effects on the secretory responses in Pavlov pouch dogs.