Population Dynamics in the Evolution of RNA Viruses
- 1 January 1998
- book chapter
- Published by Springer Nature
- Vol. 440, 721-727
- https://doi.org/10.1007/978-1-4615-5331-1_93
Abstract
RNA virus quasispecies are subjected to processes of positive Darwinian selection, to a very active and continuous negative selection and to random genetic drift. The course of RNA virus evolution is often unpredictable, and recent results suggest that even highly conserved motifs, once regarded as essential for infectivity, may be rendered dispensable by singular evolutionary events. An immediate consequence of the quasispecies genetic organization of RNA viruses is a surprising ability to gain fitness once a minimal replication ability is established in a biological enviroment. The unique features of RNA genetics should not be underestimated since they are at the basis of the emergence of new viral diseases and of the current difficulties to control many diseases associated variable viruses.Keywords
This publication has 26 references indexed in Scilit:
- RNA VIRUS MUTATIONS AND FITNESS FOR SURVIVALAnnual Review of Microbiology, 1997
- Genetic Lesions Associated with Muller's Ratchet in an RNA VirusJournal of Molecular Biology, 1996
- Induced Pocket to Accommodate the Cell Attachment Arg-Gly-Asp Motif in a Neutralizing Antibody Against Foot-and-Mouth-Disease VirusJournal of Molecular Biology, 1996
- Lack of evidence for proofreading mechanisms associated with an RNA virus polymeraseGene, 1992
- Fitness of RNA virus decreased by Muller's ratchetNature, 1990
- A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype CJournal of General Virology, 1990
- The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolutionNature, 1989
- The neutral theory of molecular evolution and the world view of the neutralistsGenome, 1989
- Isolation and Characterization of Conditional Lethal Amber Nonsense Mutants of Vesicular Stomatitis VirusJournal of General Virology, 1987
- An inducible mammalian amber suppressor: Propagation of a poliovirus mutantCell, 1987