DEMONSTRATION OF HORMONAL SENSITIVITY IN GYNAECOMASTIC TISSUE BY THYMIDINE INCORPORATION IN VITRO
- 1 March 1977
- journal article
- Published by Wiley in Acta Pathologica Microbiologica Scandinavica Section A Pathology
- Vol. 85A (1) , 19-24
- https://doi.org/10.1111/j.1699-0463.1977.tb03863.x
Abstract
Gynaecomastic tissue from six patients were tested for oestrogen and testosterone sensitivity as measured by thymidine incorporation in tissue fragments in vitro. The DNA synthesis of the cultures was increased in tissue from five out of the six patients under the influence of oestrogen, whereas it was increased in tissue from only one patient under the influence of testosterone. The results are discussed in relation to the medical histories of the patients and hormonal excretion studies done by others.Keywords
This publication has 20 references indexed in Scilit:
- Oestrogen-responsive human breast cancer in long term tissue cultureNature, 1975
- Effect of testosterone and estradiol-17β on synthesis of dna, rna and protein in human breast in organ cultureInternational Journal of Cancer, 1975
- TISSUE-CULTURE MICROTEST FOR PREDICTING RESPONSE OF HUMAN CANCER TO CHEMOTHERAPYThe Lancet, 1974
- CORRELATION BETWEEN THE EFFECTS OF HORMONES ON THE SYNTHESIS OF DNA IN EXPLANTS FROM INDUCED RAT MAMMARY TUMOURS AND THE GROWTH OF THE TUMOURSJournal of Endocrinology, 1974
- ARE SOME WOMEN'S BREAST CANCERS ANDROGEN DEPENDENT ?The Lancet, 1973
- PROLACTIN DEPENDENCE IN HUMAN BREAST CANCERSThe Lancet, 1972
- IN-VITRO ŒSTROGEN SENSITIVITY OF BREAST-CANCER TISSUE AS A POSSIBLE SCREENING METHOD FOR HORMONAL TREATMENTThe Lancet, 1972
- Hormonal Dependence of DNA Synthesis in Mammary Carcinoma Cells in vitroScience, 1968
- Effect of chemotherapeutic agents and hormones on organ cultures of human tumoursPublished by Elsevier ,1968
- Hormone Excretion Studies of Gynaecomastia of PubertyBMJ, 1964