Periconceptional Use of Multivitamins and the Prevalence of Neural-Tube Defects
- 12 April 1990
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 322 (15) , 1082-1084
- https://doi.org/10.1056/nejm199004123221513
Abstract
Although the Journal's policy on the publication of negative results (Aug. 17 issue)1 is laudable, I cannot agree with Dr. Angell's assessment that the chosen example of a negative study2 was "carefully designed and analyzed." At least three flaws in the study of Mills et al. on the periconceptional use of vitamins and neural-tube defects2 are serious enough to render its results and conclusions untenable.Keywords
This publication has 9 references indexed in Scilit:
- Multivitamin/Folic Acid Supplementation in Early Pregnancy Reduces the Prevalence of Neural Tube DefectsJAMA, 1989
- NewsBMJ, 1989
- Negative StudiesNew England Journal of Medicine, 1989
- The Absence of a Relation between the Periconceptional Use of Vitamins and Neural-Tube DefectsNew England Journal of Medicine, 1989
- PREVENTION OF NEURAL TUBE DEFECT RECURRENCES IN YORKSHIRE: FINAL REPORTThe Lancet, 1989
- Vitamin A-Induced Suppression/Enhancement of Protein Glycosylation and NeurulationPediatric Neurosurgery, 1987
- Neural‐tube defects and vitamins: the need for a randomized clinical trialBJOG: An International Journal of Obstetrics and Gynaecology, 1984
- Prevention of neural tube defects in an urban health district.Journal of Epidemiology and Community Health, 1983
- Prospective versus retrospective approach in the search for environmental causes of malformations.American Journal of Public Health and the Nations Health, 1967