Clinical Synovitis and Radiological Lesions in Rheumatoid Arthritis: A Prospective Study of 25 Patients during Treatment with Remission-inducing Drugs

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Abstract
The joints of hands and feet of 25 patients (1150 joints) with rheumatoid arthritis were compared, joint by joint, clinically and radiologically, over 2 years of treatment with remission-inducing drugs. Joints with clinical signs of synovitis decreased from 47% to 17% (ppppp<0.001), the difference in radiological progression between the latter two groups being non-significant. Twenty-one per cent of the joints with progressive bone lesions had no clinical signs of synovitis during the period.