LÖFFLER'S ENDOCARDITIS AND ENDOMYOCARDIAL FIBROSIS-A NOSOLOGIC ENTITY?

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Abstract
Whether Loffler''s endocarditis and endomyocardial fibrosis belong to the same disease spectrum or are separate entities is still debatable. Until recently it was believed that endomyocardial fibrosis was a disorder restricted to tropical areas. Three Danish patients are presented, 2 showing a continuous disease spectrum, 1 patient showing the fully developed endomyocardial fibrosis which is indistinguishable from endomyocardial fibrosis described from the tropical areas. Eosinophilia was present in all 3 patients. The hypothesis that Loffler''s endocarditis and endomyocardial and endomyocardial fibrosis belong to the same disease spectrum and that the eosinophilic granulocyte may be the underlying cause was supported.