Involvement of nitric oxide synthesis in hepatic perturbations induced in rats by a necrogenic dose of thioacetamide
- 1 June 1997
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 121 (4) , 820-826
- https://doi.org/10.1038/sj.bjp.0701191
Abstract
The biological actions of nitric oxide (NO), a highly diffusible and short‐lived radical, range from signal transduction to cytotoxicity. The present study investigated whether NO is released in the course of liver necrosis and regeneration induced by a single necrogenic dose of thioacetamide (6.6 mmol kg−1 body wt) to rats. Samples of liver were obtained at 0, 3, 12, 24, 48, 72 and 96 h after thioacetamide administration. Inducible nitric oxide synthase (iNOS) activity was determined in purified liver homogenates and a sharp 6 fold increase (PPPPPPPBritish Journal of Pharmacology (1997) 121, 820–826; doi:10.1038/sj.bjp.0701191Keywords
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