Induction of delta‐aminolaevulinic acid synthase in leucocytes of patients on phenytoin therapy‐comparison with changes in rat hepatic tissue.

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Abstract
1 In rats daily phenytoin (DPH) administration resulted in an increase in hepatic cytochrome P450 content. The rise in cytochrome P450 was associated with a temporary increase in the acitvity of hepatic delta‐ aminolaevulinic acid (ALA) synthase. 2 In patients newly commenced on DPH anticonvulsant therapy the activity of ALA synthase in peripheral leucocytes showed a marked temporary increase during the first 10 days of therapy. 3 These findings suggest that DPH induces a haem‐requiring eenzyme system in peripheral leucocytes as well as in hepatic tissue.

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