Essential Fatty Acid Deficiency and Rat Liver Homogenate Oxidations

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Abstract
Essential fatty acid deficiency (EFA) in rats, whether induced by a diet containing no fat or a large quantity of saturated fat, results in an increased oxidation of practically all of the citric acid cycle intermediates, pyruvate, and caprylate by liver homogenates. This increase was detectable after rats are fed a high fat diet for two weeks, and a fat-free diet for four weeks. These elevated oxidative rates were reduced to the normal range within one week after feeding a source of EFA. Fractionation of liver homogenates revealed that the greatest effect of EFA deficiency is associated with the debris fraction. However, the isolated mitochondria from deficient rats, nevertheless, showed an increased oxidation rate when the results are expressed on an equivalent nitrogen basis.

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