Molecular Communication through Stochastic Synchronization Induced by Extracellular Fluctuations
- 19 October 2005
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 95 (17) , 178103
- https://doi.org/10.1103/physrevlett.95.178103
Abstract
We model a synthetic gene regulatory network in a microbial cell, and investigate the effect of noises on cell-cell communication in a well-mixed multicellular system. A biologically plausible model is developed for cellular communication in an indirectly coupled multicellular system. Without extracellular noises, all cells, in spite of interaction among them, behave irregularly due to independent intracellular noises. On the other hand, extracellular noises that are common to all cells can induce collective dynamics and stochastically synchronize the multicellular system by actively enhancing the integrated interchange of signaling molecules.Keywords
This publication has 15 references indexed in Scilit:
- CCN proteins, microenvironment, communication and signaling: why did we need a new journal?Journal of Cell Communication and Signaling, 2007
- Noise-induced cooperative behavior in a multicell systemBioinformatics, 2005
- Design of artificial cell–cell communication using gene and metabolic networksProceedings of the National Academy of Sciences, 2004
- Summing up the noise in gene networksNature, 2004
- Chemical communication among bacteriaProceedings of the National Academy of Sciences, 2003
- Stochastic Gene Expression in a Single CellScience, 2002
- Synchronizing genetic relaxation oscillators by intercell signalingProceedings of the National Academy of Sciences, 2002
- Interacting Coherence Resonance OscillatorsPhysical Review Letters, 1999
- Stochastic resonance: Noise-enhanced phase coherencePhysical Review E, 1998
- Stochastic Processes in Physics and ChemistryPhysics Today, 1983