Detection of Focal Hepatic Lesions
- 1 February 1998
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Investigative Radiology
- Vol. 33 (2) , 61-67
- https://doi.org/10.1097/00004424-199802000-00001
Abstract
The authors evaluate the value of two fast spin-echo sequences (FSE) with different T2-weighting (repetition time [TR]/echo time [TE] = 2000/90 mseconds and TR/TE = 2000/40 mseconds) and combined gradient-and-spin-echo sequences (TR/TE = 2000/90 mseconds) for contrast-enhanced liver imaging with superparamagnetic iron oxide (AMI-25). Forty-seven patients with focal liver lesions underwent magnetic resonance imaging at 1.0 tesla. AMI-25 was administered intravenously at a dose of 15 micromol iron/kg. Administration of AMI-25 resulted in a significant increase of lesion/liver contrast-to-noise ratio (C/N) for all T2-weighted sequences (P < 0.001). On the precontrast images, the FSE sequence with a TE of 90 mseconds had the highest C/N (16.0 +/- 4.5) whereas the best postcontrast C/N (27.9 +/- 7.6) was obtained with the mild T2-weighted FSE sequence with a TE of 40 mseconds. Fast spin-echo sequences are valuable sequences for imaging of the liver at 1.0 tesla. For AMI-25-enhanced magnetic resonance imaging, a mild T2-weighted FSE sequence is recommended.Keywords
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