Proliferation of C3HXCBA Hybrid Lymphocytes in the Spleens of Irradiated CBA Mice: Inhibition of this Phenomenon by Pretreatment of the Hosts with C3HXCBA Spleen Cells

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Abstract
Lymphocytes from C3H .times. CBA hybrid mice proliferate intensely in spleens of irradiated CBA mice. Pretreatment of the CBA hosts with C3H .times. CBA spleen cells, known to specifically reduce T [thymus-derived] cell reactivity of the hosts against the strongly stimulatory Mls-antigen determined by the C3H-genome, abolished the capacity of the host to promote proliferation of C3H .times. CBA lymphocytes. Proliferation of C3H .times. CBA bone marrow cells, as measured by spleen cell populations of (C3H .times. CBA) .times. CBA back-cross mice to inhibit lymphocyte proliferation and to express the C3H-determined Mls-antigen, it was concluded that these 2 traits are associated.