Semisynthetic Penicillins. V. alpha-(Ylideneimino-oxy)penicillins.

Abstract
The synthesis and antibacterial properties of a series of [alpha]-(ylideneimino-oxy) penicillins are reported. The new penicillins were obtained by coupling [alpha]-(ylideneimino-oxy)carboxylic acid chlorides to 6-amino-penicillanic acid. Among the prepared penicillins, 6-[D([long dash])-[alpha]-(2-chloro-benzylideneimino- oxy) - [alpha] -phenylacetamido]penicillanic acid showed the best effect against Escherichia coli.

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