HOST SERUM-PROTEINS IN ECHINOCOCCUS-MULTILOCULARIS - COMPLEMENT ACTIVATION VIA CLASSICAL PATHWAY

  • 1 January 1977
    • journal article
    • research article
    • Vol. 33  (1) , 1-9
Abstract
The presence of host [Sigmodon hispidus] serum proteins, including Ig[immunoglobulin]G and IgM, within the cyst membranes and on the surface of protoscoleces of E. multilocularis was demonstrated by the use of HRPO[horseradish peroxidase]-conjugated purified antisera. Viable protoscoleces incubated in EDTA- or EGTA[ethylene glycol bis(.beta.-aminoethyl ether)tetracetic acid]-fresh human sera were not lysed; the addition of Ca restored protoscolecidal activity of the EGTA serum. The complement-mediated lysis of this metazoan organism proceeds via the classical pathway of complement activation. Results are discussed in relation to the ability of this parasite to survive in the immunologically hostile environment of the host.

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