STUDIES IN STEROID METABOLISM. XXVII. A COMPARISON OF THE STEROID RESPONSE TO ACTH AND CORTISONE IN NORMAL YOUNG MEN 1

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Abstract
Qualitative and quantitative pattern of ketosteroid response was studied in 2 normal young men treated experimentally with large doses of oral cortisone acetate and intravenous ACTH. Conclusions were drawn concerning metabolic pathways utilized when large doses of adrenal hormones are provided from exogenous, as compared with endogenous sources. In the latter situation the ketosteroid response indicates the existence of a C19-11-desoxy substance of adrenal origin. This hormonal substance, we conclude from a consideration of available data may represent adrenocortical production of testosterone or a chemically closely related compound and the metabolites may thus be a measure of the primary adrenal androgen.

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