Spontaneous regression of plane warts after inflammation: clinical and histologic studies in 25 cases
- 1 September 1977
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 113 (9) , 1209-1213
- https://doi.org/10.1001/archderm.113.9.1209
Abstract
Based on clinical and histological studies in 25 patients, plane warts apparently show a characteristic phenomenon of spontaneous regression totally distinct from that described in common warts. This regression developed during various treatments in 9 cases; in 16 case it occurred spontaneously. In all the patient there was a sudden and systemic onset of inflammation in every flat wart. Within 2-6 wk all the warts completely involuted. Histologically, there were variable degrees of epidermal changes depending on the stage of inflammation. A mononuclear cell infiltration with epidermal invasion was demonstrated in every biopsy specimen. This regressive phenomenon of plane wart is probably mediated by cellular immunity. It represents a natural experimental model of rejection of tumors induced by papovavirus in humans.This publication has 1 reference indexed in Scilit:
- Antitumor Immunity in the Shope Papilloma-Carcinoma Complex of Rabbits, I. Papilloma Regression Induced by Homologous and Autologous Tissue Vaccines2JNCI Journal of the National Cancer Institute, 1962