RECEPTORS FOR ACTIVATED C-3 ON THYMUS-DEPENDENT LYMPHOCYTES-T OF NORMAL GUINEA-PIGS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 37  (2) , 377-384
Abstract
In a survey of lymphocyte subpopulations in normal guinea-pig blood, lymph node, spleen, thymus and peritoneal cavity, a considerable overlap was observed between the percentages of C3[complement component 3]-receptor bearing lymphocytes (CRL) and of thymus dependent (T) cells in lymph nodes. Simultaneous rosette-forming reactions with sheep erythrocytes carrying rabbit complement (EAC) and papain-treated rabbit erythrocytes (a T cell marker) revealed that 20-50% of the lymph node CRL were T lymphocytes. These experiments and others on cell suspensions depleted of Ig[immunoglobulin]-bearing (B) lymphocytes showed that between 8-36% of lymph node T cells have complement receptors. The frequency of T-CRL in other lymphoid tissues was lower, representing between 0 and 8% of the T cell population. The reaction of T-CRL and EAC was not inhibited by EDTA which is known in inhibit the C3 receptor activity on macrophages.

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