ENHANCEMENT BY CORYNEBACTERIUM-PARVUM OF NORMAL AND TUMOR TISSUE-RESPONSE TO HYPERTHERMIA

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (3) , 862-864
Abstract
The effect of C. parvum treatment on the response of tumor and normal tissue to hyperthermia (43.5.degree.) was studied. Animals were C3Hf/Sed mice from a defined flora mouse colony. The time at hyperthermia that achieved control of 1/2 of methylcholanthrene-induced fibrosarcomas and the foot reaction were examined after treatment. C. parvum, if given 3-32 days before hyperthermia, enhanced the reaction to local hyperthermia of normal tissue. No enhancement was observed if C. parvum was given after hyperthermia. This enhancement was more dramatic for tumor response resulting in a therapeutic gain factor of .simeq. 2.3 (3.7/1.6). Comparative studies on combined Corynebacterium and radiation failed to demonstrate the enhancement to normal tissue.

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