AN INVESTIGATION OF THE COAGULATION DEFECT BROUGHT ABOUT IN RABBITS AND DOGS BY THE INTRAVENOUS INJECTION OF PAPAIN

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Abstract
The intravenous injection of papain causes the blood of dogs and rabbits to become incoagulable. In rabbits the incoagulability persists for many hours. In some animals there remained a mild disturbance in the coagulation system up to two weeks after the injection. The release of heparin can account for part of the effect, but there is evidence of some other contributing factor. Results indicate that the added factor affects the thrombin–fibrinogen reaction. Calcium chloride in excess of that needed for normal coagulation will greatly inhibit the antithrombic effect of commercial beef heparin, and to a lesser extent, the antithrombic effect of an injection of papain.

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