Sleep and Sleep Homeostasis in Mice Lacking the 5-HT2c Receptor
Open Access
- 26 April 2002
- journal article
- research article
- Published by Springer Nature in Neuropsychopharmacology
- Vol. 27 (5) , 869-873
- https://doi.org/10.1016/s0893-133x(02)00353-6
Abstract
Studies in humans and rats indicate that serotonin (5-hydroxytryptamine, 5-HT) receptors are involved in mammalian sleep expression. We investigated the contribution of the 5-HT2c receptor to sleep expression by examining sleep patterns in mice bearing a targeted null mutation of this receptor. 5-HT2c receptor knock-out mice had more wakefulness, several abnormalities in rapid eye movement sleep expression and an enhanced response to sleep deprivation compared with wild-type control mice. These findings suggest that 5HT2c receptors may mediate several effects on sleep that have been ascribed to serotonin.Keywords
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