THE INFLUENCE OF ADRENAL CORTICAL HORMONE UPON ELECTROLYTE AND FLUID DISTRIBUTION IN ADRENALECTOMIZED DOGS MAINTAINED ON A SODIUM AND CHLORIDE FREE DIET

Publisher Website
Google Scholar
Abstract
The normal dog with intact adrenals when kept on a salt-free diet for 2 weeks retains his normal health and vigor. The serum Na and chloride do not change appreciably but some hemoconcentration may occur. In healthy, vigorous, adrenalectomized dog maintained on a Na- and chloride-free diet, urinary loss of Na, chloride, and water were not necessary accompaniments of severe adrenal insufficiency; and severe adrenal insufficiency with hemoconcentration, dehydration and circulatory collapse could occur in the absence of significant change in the level of the serum Na and chloride. Under the conditions of the experiments the serum potassium changes were not significant. The mobilization and redistribution of body fluid which follow hormone injection are evidently associated with a redistribution of electrolytes. The increases in serum Na and chloride during recovery are, to a large extent, masked by a simultaneous expansion in volume of the extracellular fluid.

This publication has 3 references indexed in Scilit: