Effect of Hyaluronidase on Inflaniination

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Abstract
Hyaluronidase modifies the inflammatory response of tissue due to certain oil and water-soluble irritants. Paraphenylenediamine hydrochloride dissolved in physiological saline, and allyliso-thiocyanate dissolved in mineral oil were injected intradermally with and without hyaluronidase in 46 rabbits. Trypan blue was injected intraven. and the spread of the dye in the tissues, representing increased vascular permeability, appears earlier and is greater when the irritants are admn. with hyaluronidase; and where the nature of the irritant is such as to produce hemorrhages, the areas of these hemorrhages are also greater and occur earlier. Hyaluronidase does not alter the solubility or absorption of an oil-soluble irritant; however its use with oil or water-soluble irritants eliminates edema from the classical picture of inflammation. This may have practical applicability where prevention of edema resulting from contact with irritants is important.

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