Cortisone and Action of Exogenous Thyrotrophin in Hypophysectomized Rats.

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Abstract
Groups of hypophysectomized rats were given 5 mg. of cortisone daily, 03 mg. of thyrotropin (TSH) daily, and 5 mg. of cortisone + 0.3 mg-TSH daily for 10 days. The avg. thyroid cell height was 4.1 [mu] in the hypophysectomized controls, 4.3 [mu]. in the cortisone-treated rats, 8.0 [mu] in the rats treated with TSH, and 9.1 [mu]. in the animals which received both TSH and cortisone. Cortisone, under the conditions of the expt., did not block and probably even slightly enhanced the effect of TSH on the thyroid.