The renal kallikrein-kinin system.

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Abstract
The renal kallikrein-kinin system [human, rat, dog] is an important part of an intrarenal hormonal regulatory complex which also includes renin-angiotensin, prostaglandins and aldosterone. The kallikrein system is apparently a significant factor in the control of the renal circulation and of salt and water excretion. It is possible that abnormalities of this system play a role in the pathogenesis or pathophysiology of some forms of hypertension, kidney disease and fluid and electrolyte disorders. The results of previous investigations appear to justify the current rapid expansion of research in this area.