Direct β-Alkylation of Secondary Alcohols with Primary Alcohols Catalyzed by a Cp*Ir Complex
- 2 August 2005
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (18) , 4017-4019
- https://doi.org/10.1021/ol051517o
Abstract
A new catalytic system for beta-alkylation of secondary alcohols has been developed. In the presence of [CpIrCl(2)](2) (Cp = pentamethylcyclopentadienyl) catalyst and base, the reactions of various secondary alcohols with primary alcohols give beta-alkylated higher alcohols in good to excellent yields without any hydrogen acceptor or hydrogen donor. This reaction proceeds via successive hydrogen-transfer reactions and aldol condensation. [reaction: see text]Keywords
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